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Differences What are the advantages of each

Front view of AMD Third Generation Opteron 8300

Reasons to consider the
AMD Third Generation Opteron 8300

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Much higher clock speed 2.3 GHz vs 1.8 GHz Around 30% higher clock speed
Supports more CPUs in SMP configuration 8 vs 4 Twice as many CPUs in SMP configuration
More l3 cache per core 1.5 MB/core vs 1 MB/core 50% more l3 cache per core
Front view of AMD Opteron 6366 HE

Reasons to consider the
AMD Opteron 6366 HE

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Much more l2 cache 16 MB vs 2 MB 8x more l2 cache; more data can be stored in the l2 cache for quick access later
Much more l3 cache 16 MB vs 6 MB Around 2.8x more l3 cache; more data can be stored in the l3 cache for quick access later
More threads 16 vs 4 12 more threads
More cores 16 vs 4 12 more cores; run more applications at once
Much more l2 cache per core 1 MB/core vs 0.5 MB/core 2x more l2 cache per core
Newer manufacturing process 32 nm vs 45 nm A newer manufacturing process allows for a more powerful, yet cooler running processor

Features Key features of the Third Generation Opteron 8300  vs Opteron 6366 HE 

Specifications Full list of technical specs

summary

Third Generation Opteron 8300  vs
Opteron 6366 HE 
Clock speed 2.3 GHz 1.8 GHz
Cores Quad core 16 core

features

Has a NX bit Yes Yes
Has virtualization support Yes Yes
Instruction set extensions
SSE4a
AVX 1.1
SSE2
F16C
MMX
XOP
AVX
SSE3
SSE
ABM
BMI1
CLMUL
AMD64
SSE4.1
FMA4
FMA3
SSE4.2
CVT16
AMD-V
3DNow!
Supplemental SSE3
AES
TBM
Supports dynamic frequency scaling Yes Yes

details

Third Generation Opteron 8300  vs
Opteron 6366 HE 
Threads 4 16
L2 cache 2 MB 16 MB
L2 cache per core 0.5 MB/core 1 MB/core
L3 cache 6 MB 16 MB
L3 cache per core 1.5 MB/core 1 MB/core
Manufacture process 45 nm 32 nm
Max CPUs 8 4

power consumption

Typical power consumption N/A 69.06W
AMD Third Generation Opteron 8300
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AMD Opteron 6366 HE
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